Getting random with thermal noise
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چکیده
which typically has a greater stiffness in tumors than in surrounding normal tissues. Exploiting this difference, Liu et al. engineered mechanoresponsive mesenchymal stem cells to act as vehicles for cancer drug delivery in a mouse model. The engineered stem cells accumulated in tumors, delivering the first half of a two-part cancer therapy: the enzyme cytosine deaminase. Subsequently, the drug 5-fluorocytosine was delivered systemically, and the cytosine deaminase present in the tumor environment activated the drug to supply local anticancer therapy with no off-target damage. —YN Sci. Transl. Med. 9, eaan2966 (2017).
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